Cell Damage May Be Caused by Exogenous Sources Such as

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The shift in the balance between oxidants and antioxidants in favor of oxidants is termed oxidative stress Regulation of reducing and oxidizing redox state is critical for cell viability activation proliferation and. At the cellular level.


Endogenous And Exogenous Agents Causing Dna Damage Oxidative Stress Download Scientific Diagram

At high concentrations however free radicals can be hazardous to the body and damage all major components of cells including DNA proteins and cell membranes.

. DNA damage is a fact of life as a consequence of endogenous sources and processes as well as exogenous sources 1Homologous recombination HR is a DNA metabolic process found in all forms of life. The damage to cells caused by free radicals especially the damage to DNA may play a role in the development of cancer and other health conditions 1 2. Replication may also be blocked or the cell may die.

A mutation cannot be recognized by enzymes once the base change is present in both DNA strands and thus a mutation cannot be repaired. DNA damage can also be caused by substances produced in the body. ROS are highly reactive molecules and can damage cell structures such as carbohydrates nucleic acids lipids and proteins and alter their functions.

Such exogenous and endogenous sources of DNA damage are indicated in the boxes at the top of the figure in this section. Exogenous damage caused by external agents such as ultraviolet. The central role of DNA damage in progression to cancer is indicated at the second level of the figure.

In contrast to DNA damage a mutation is a change in the base sequence of the DNA. The contribution of oxidative stress-caused mitochondrial damage in Alzheimers disease Parkinsons disease and amyotrophic lateral sclerosis is summarized and analyzed in a broad attempt to provide evidence for the potential treatment of neurodegenerative diseases. The central elements of DNA damage epigenetic alterations and deficient DNA.

Neurodegenerative diseases including Alzheimers disease AD Parkinsons.


Dna Damage Response R D Systems


Types Of Free Radicals Oxidants And Their Endogenous And Exogenous Download Scientific Diagram


Reactive Oxygen Species Ros Can Be Produced By 1 Exogenous Sources Download Scientific Diagram

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